Fetuin (Alpha-2-Heremans-Schmid Glycoprotein) Serum Concentration
This test measures the level of fetuin, a protein found in your blood serum. It may be checked to assess kidney function, bone health, or certain metabolic conditions.
["Fetuin levels can help evaluate kidney and bone health, though they’re not as commonly monitored as other blood tests."]
Key facts at a glance
- LOINC
- 11627-7
- Short code
- Fet AFI sum der US
- Synonyms
- Fet AFI sum der US
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- us-derived
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Might This Test Be Ordered?
Your healthcare provider may order this test if you have symptoms or conditions linked to kidney disease, bone disorders (like osteoporosis), or metabolic issues. It could also be part of a broader evaluation for unexplained health concerns or monitoring chronic conditions.
What Does the Test Measure?
Fetuin is a protein that helps regulate calcium and phosphate levels in your body. Low levels may indicate problems with kidney function or bone metabolism, while higher levels might be associated with certain metabolic disorders.
Sample Collection and Preparation
A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum (the liquid part after clotting), which is then analyzed for fetuin concentration. No special preparation is needed, but fasting may be advised depending on your provider’s instructions.
What to Expect During the Test
The blood draw is quick and typically painless. You may feel a slight pinch, but most people tolerate it well. The serum is sent to a lab for analysis, and results are usually available within a few days.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Fetuin plays a role in calcium metabolism and may be linked to conditions like chronic kidney disease, where its levels can drop. In bone health, low fetuin might suggest increased bone turnover or metabolic bone disease. While less common, elevated levels could indicate certain metabolic or inflammatory conditions, though further evaluation would be needed.
Short name
Fetuin Level
Frequently asked questions
How long does it take to get my results?
What are typical reference ranges?
Can I fast before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy