Folate in Serum (Concentration)
This test measures the amount of folate, a B vitamin essential for red blood cell production and DNA synthesis, found in your blood serum.
["Helps assess vitamin B9 levels and potential deficiencies affecting red blood cells and pregnancy health."]
Key facts at a glance
- LOINC
- 12167-3
- Short code
- Fet AF space Imp Vol amnio fld US
- Synonyms
- Fet AF space Imp Vol amnio fld US
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 7.5
- Ref high
- 11.5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- us
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to check for folate deficiency, which can cause anemia, fatigue, or neurological issues. It’s often recommended during pregnancy to prevent birth defects or in cases of poor diet, alcohol use, or certain medications that deplete folate.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the draw if fasting samples are required for accuracy. Wear comfortable clothing and bring your medical records if you have conditions like kidney disease or autoimmune disorders.
How the Test Works
A blood sample is taken from a vein in your arm. The blood is processed to separate serum, which is then analyzed using a specialized immunoassay method to measure folate concentration.
What the Results Mean
Results are compared to standard reference ranges for your age, sex, and health status. Low levels may indicate deficiency, while high levels could suggest liver disease, certain medications, or overconsumption of folate supplements.
Reference range
Adult: 7.5-11.5 fLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Serum Folate
Frequently asked questions
Low folate levels can lead to anemia, birth defects in pregnancy, or increased risk of certain cancers. High levels may mask vitamin B12 deficiency (which can cause neurological damage) and are sometimes seen in conditions like alcoholism or chronic liver disease.
This test is typically done alone but may be part of a broader panel if you have symptoms like unexplained fatigue, pale skin, or digestive issues.
Yes, if you’re pregnant, low folate is linked to neural tube defects in the baby. Your doctor may adjust prenatal vitamin doses or monitor levels closely.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy