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Fetuin (Alpha-2-Heremans-Schmid Glycoprotein) Quantitative Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of fetuin, a protein produced mainly in the liver, in your blood. It may be checked to assess liver function, kidney health, or certain metabolic conditions.

Quick summary

["Fetuin levels can help identify potential liver or kidney issues or metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53656-5
Short code
Fet Hrt Diam AP US.meas
Synonyms
Fet Hrt Diam AP US.meas
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-measured
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms or conditions linked to liver disease, kidney problems, or metabolic disorders. For example, it might be used to monitor liver function in chronic liver diseases or to evaluate protein metabolism in certain genetic conditions.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for a few hours before the blood draw, but always follow your provider’s instructions. Avoid smoking or consuming alcohol for at least 24 hours before the test if directed.

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but the procedure usually takes a few minutes. The blood sample will be sent to a lab for analysis.

The test involves collecting a small amount of blood, usually from your arm. The blood is then processed and analyzed to measure the concentration of fetuin in your serum or plasma.

What the Results Mean

Results are interpreted by your healthcare provider based on your medical history, symptoms, and other test results. Abnormal levels may suggest liver disease, kidney dysfunction, or metabolic issues, but they are not definitive on their own.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Fetuin is involved in regulating calcium metabolism and may play a role in liver fibrosis, kidney disease, and certain metabolic syndromes. Elevated levels could indicate liver dysfunction or other metabolic disturbances, while low levels may be associated with conditions affecting protein synthesis or kidney function. Always discuss results with your provider for personalized interpretation.

Short name

Fetuin Level

Frequently asked questions

How long does it take to get the results of this test?
Results are usually available within 1 to 3 business days, depending on your lab’s processing time. Your healthcare provider will contact you once they have the results to discuss them further.
What are the common causes of abnormal fetuin levels?
Abnormal fetuin levels can result from liver diseases (such as cirrhosis or hepatitis), kidney problems (like chronic kidney disease), or metabolic disorders. Other conditions, such as malnutrition or certain genetic disorders, may also affect fetuin levels. Your provider will consider your overall health and other test results to determine the cause.
Is fasting required for this test?
Fasting may be recommended, but it is not always required. Always follow your healthcare provider’s specific instructions for preparation. If in doubt, ask your provider before the test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy