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Folate and Vitamin B12 Screening Panel (Serum)

Published: August 9, 2026Updated: August 16, 2026

This blood test checks your levels of folate (a B vitamin) and vitamin B12 (another B vitamin essential for nerve function and red blood cell production). Low levels may indicate nutritional deficiencies or underlying health conditions.

Quick summary

["Checks if you may have vitamin deficiencies that could affect energy, blood health, or nerve function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39153-2
Short code
FFDM Brst screening
Synonyms
FFDM Brst screening
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mg-ffd
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, weakness, or numbness in your hands and feet. It’s also recommended for pregnant women, people with certain medical conditions (like anemia or heart disease), or those on medications that may deplete these vitamins.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if folate levels are being measured. Bring any medications you’re currently taking to your appointment.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm. The process takes a few minutes, and you may feel a slight pinch. The blood sample is sent to a lab for analysis.

What the Results Mean

Results show your vitamin levels. Low levels of either vitamin may need further investigation or treatment, such as dietary changes or supplements. High levels may not require immediate action but should be discussed with your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Folate & B12 Screening

Frequently asked questions

What causes low vitamin levels?
Low levels can result from poor diet (low intake of leafy greens, meat, or fortified foods), malabsorption issues (like celiac disease or stomach disorders), or certain medications. Lifestyle factors, such as heavy alcohol use, may also contribute.
Can I take supplements to prevent deficiency?
Supplements can help, but they’re not a substitute for a balanced diet. Always follow your healthcare provider’s advice, especially if you’re pregnant or have a known deficiency.
How often should I get this test?
Your provider will determine frequency based on your health status. Typically, it’s recommended every 1–3 years for adults at risk, or more often if you have conditions like pernicious anemia or chronic kidney disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy