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Fibrinogen Mutation Testing via Whole Blood DNA Analysis

Published: August 9, 2026Updated: August 16, 2026

This test checks for mutations in the *FGB* gene, which codes for fibrinogen—a protein involved in blood clotting. Mutations here may increase your risk of bleeding disorders or clotting issues.

Quick summary

["This test helps identify genetic changes linked to bleeding or clotting risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
59046-3
Short code
FGB Mut Tested Bld/T
Synonyms
FGB Mut Tested Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have a family history of bleeding disorders (like von Willebrand disease), unexplained bleeding, or clotting problems. It’s also used in genetic counseling for inherited conditions.

What to Expect Before the Test

You’ll provide a small blood sample (like a standard blood draw). No special preparation is needed, but avoid strenuous activity 24 hours before. The test analyzes DNA from your white blood cells.

What the Results Mean

Results show whether specific mutations in the *FGB* gene are present. Positive findings may require further evaluation by a genetic specialist or hematologist to assess risk or guide treatment options.

Common Causes for Testing

This test is often done when a doctor suspects hereditary bleeding disorders, especially if family members have had similar issues. It’s also part of pre-surgical screening for high-risk procedures.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

FGB Mutation Screening (blood DNA)

Frequently asked questions

What does this test measure?
This test detects genetic mutations in the *FGB* gene, which encodes fibrinogen—a protein critical for blood clotting. Mutations here can lead to either excessive bleeding (if fibrinogen is too low) or clotting disorders (if fibrinogen function is impaired).
How long will results take?
Results typically take 2–4 weeks, depending on lab processing and genetic analysis timelines. Your doctor will contact you once results are ready.
Can I get this test at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting. Home DNA collection kits are not used for this specific test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy