Fibrillarin Antibody (Serum) – Line Blot Assay
This test detects antibodies against fibrillarin, a protein found in certain cells, often used to evaluate autoimmune conditions affecting the kidneys or other organs. It may be ordered if you have symptoms like kidney problems, unexplained fatigue, or other signs of autoimmune disease.
["This test helps identify potential autoimmune responses linked to rare conditions like systemic sclerosis or other connective tissue disorders."]
Key facts at a glance
- LOINC
- 82394-8
- Short code
- Fibrillarin Ab Ser Ql Line blot
- Synonyms
- Fibrillarin Ab Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The line blot assay detects the presence of antibodies specific to fibrillarin, a nuclear protein involved in ribosomal RNA processing. This method visualizes these antibodies on a membrane, allowing for qualitative detection.
Why Might Your Doctor Order This Test?
Your doctor may recommend this test if you have symptoms suggestive of autoimmune kidney disease (e.g., lupus nephritis, anti-ribosomal P antibody syndrome) or other connective tissue disorders. It’s sometimes used alongside other tests to narrow down possible diagnoses.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample drawn from your arm, typically in a clinic or lab. The sample is processed and sent to a lab for analysis.
What to Expect After the Test
Results are usually qualitative (positive/negative) and may take several days to weeks to receive. Follow-up with your doctor will help interpret the results in the context of your symptoms and other tests.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test is primarily used as a screening or confirmatory tool for autoimmune conditions affecting the kidneys or other organs. Positive results may indicate an underlying autoimmune process, but further testing (e.g., clinical correlation, other antibody panels) is often needed to diagnose specific conditions like systemic sclerosis or lupus.
Short name
Fibrillarin Antibody Screening
Frequently asked questions
What does a positive result mean?
Can this test be used to diagnose kidney disease?
Is fasting required for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy