Fibrillarin Antibody (Serum) by Line Blot Immunoassay
This test detects antibodies against fibrillarin, a protein involved in RNA processing. It may help identify autoimmune conditions affecting ribonucleoprotein particles.
["This screening helps assess potential autoimmune disorders linked to ribonucleoprotein antibodies."]
Key facts at a glance
- LOINC
- 82915-0
- Short code
- Fibrillarin IgG Ser Ql Line blot
- Synonyms
- Fibrillarin IgG Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is This Test Measuring?
Fibrillarin is a nuclear protein found in ribonucleoprotein particles (RNPs), which play a role in gene expression. Antibodies against fibrillarin can be part of autoimmune diseases, such as systemic sclerosis or mixed connective tissue disease. This test identifies whether your blood contains these antibodies.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms or a history suggestive of autoimmune diseases, such as unexplained joint pain, skin changes, or organ involvement (e.g., lungs, kidneys). It may also be used as part of a broader evaluation for conditions like systemic sclerosis or other autoimmune disorders.
What Does a Positive Result Mean?
A positive result indicates the presence of antibodies against fibrillarin, which may suggest an autoimmune reaction targeting these proteins. This finding can support a diagnosis of certain autoimmune diseases but does not confirm a specific condition alone. Further testing and clinical correlation are needed.
What Does a Negative Result Mean?
A negative result means no detectable antibodies against fibrillarin were found in your sample. This does not rule out an autoimmune condition entirely, as other factors or different antibody targets may be involved. Your healthcare provider will discuss next steps based on your symptoms and test results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Antibodies against fibrillarin are associated with autoimmune diseases that affect connective tissues and organs. While not all positive results indicate a definitive diagnosis, they can guide further evaluation. For example, high titers may correlate with systemic sclerosis or other connective tissue disorders. Always interpret results in the context of your clinical presentation and other diagnostic findings.
Short name
Fibrillarin Antibody Screening
Frequently asked questions
How is this test different from other autoimmune antibody tests?
What are the most common autoimmune diseases linked to fibrillarin antibodies?
Will I need follow-up tests if my result is positive?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy