Non-Treponemal Rapid Plasma Reagin (RPR) Test
This test measures the presence of antibodies that may indicate exposure to certain bacteria, often used in screening for syphilis or other infections.
["The RPR test helps detect early signs of infections that your body has fought off, including some bacterial infections."]
Key facts at a glance
- LOINC
- 75172-7
- Short code
- FIRSTNONTREPONEMALTESTTITER
- Synonyms
- —
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
This test measures specific substances, markers, or cells in your body that can reveal important information about how well your organs are working, whether an infection or other condition is present, and how your overall health is doing over time.
The RPR test looks for antibodies in your blood that react with a specific substance (not the actual bacteria). These antibodies can appear after your body has been exposed to bacteria like those causing syphilis or other infections. This test is typically used as a screening tool rather than a definitive diagnosis.
Your healthcare provider may order this test to help diagnose a medical condition, monitor a health problem you already have, screen for disease before symptoms develop, or check how well your current treatment plan is working for you.
Doctors may order an RPR test if you have symptoms like sores, rashes, or other signs of infection, or if you have risk factors for certain infections. It’s also sometimes used as part of routine testing in certain medical situations.
A trained professional will collect your sample at a clinic, laboratory, or hospital. Depending on the type of test, this may involve drawing a small amount of blood from a vein in your arm, collecting a urine sample, or using a swab, and the process usually takes only a few minutes.
A blood sample is taken from a vein in your arm using a small needle. You may feel a slight pinch, but it usually doesn’t cause much discomfort. The blood is then sent to a lab for testing.
After your sample is collected, you can typically return to your normal daily activities right away. The specimen is sent to a laboratory for analysis, and your results are usually ready within a few days. Your healthcare provider will review them with you and explain what they mean.
After your blood is drawn, you can usually return to your normal activities immediately. There may be a small bruise or slight pain at the injection site, but this typically goes away quickly.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
RPR Test
Frequently asked questions
The RPR test is primarily used as a screening tool to detect early signs of infections that may require further testing or treatment. While it can indicate past or current exposure, it does not always confirm the specific infection. A positive result may prompt additional tests to identify the exact cause.
A positive RPR test suggests your body has produced antibodies in response to an infection, but it doesn’t always mean you have an active infection. It may indicate past exposure or an ongoing infection that needs further evaluation. Always discuss your results with your healthcare provider.
The frequency of this test depends on your medical history, symptoms, and risk factors. Your healthcare provider will determine if and when you need retesting. Follow their guidance closely.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy