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Antigen detection test for SARS-CoV-2 nucleocapsid protein in respiratory specimens (qualitative probe)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of SARS-CoV-2, the virus responsible for COVID-19, in your respiratory secretions (like nasal or throat swabs). It helps determine if you may be contagious, even if you’re not showing symptoms.

Quick summary

["A quick way to identify possible COVID-19 infection by detecting viral proteins in your respiratory sample."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95422-2
Short code
FLUABV + SARS-CoV-2 Pnl Resp NAA+prb
Synonyms
FLUABV + SARS-CoV-2 Pnl Resp NAA+prb
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

This test uses a probe to detect specific viral proteins called nucleocapsid antigens in your respiratory sample. If the virus is present, the test will show a positive result, indicating potential infection. Results are typically available within 15–60 minutes.

What to Expect Before the Test

No special preparation is needed. You may have a nasal or throat swab collected by a healthcare provider to gather respiratory secretions. If you’re experiencing symptoms like coughing, fever, or shortness of breath, inform your provider before testing.

What to Expect After the Test

After the test, you’ll receive a result quickly. A positive result suggests you may have an active infection and could be contagious. A negative result means the test did not detect the virus at the time of testing, but you should still follow up with your healthcare provider if symptoms persist.

When This Test Is Used

This test is commonly used for COVID-19 screening in high-risk settings, such as healthcare facilities, long-term care facilities, or during outbreaks. It may also be used in asymptomatic individuals or those with mild symptoms to assess contagiousness.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result indicates the presence of SARS-CoV-2 nucleocapsid proteins, which strongly suggest an active infection. This can help guide isolation measures and treatment decisions. A negative result does not definitively rule out infection, especially if symptoms develop later. Always consult your healthcare provider for interpretation.

Short name

SARS-CoV-2 Nucleocapsid Antigen Test (Respiratory)

Frequently asked questions

What does a positive result mean?
A positive result means the test detected viral proteins in your respiratory sample, suggesting you may have an active COVID-19 infection. You should follow isolation guidelines and contact your healthcare provider for further guidance.
Can a negative result mean I don’t have COVID-19?
A negative result means the test did not detect the virus at the time of testing, but it does not guarantee you are not infected. The virus may not yet be present in your respiratory sample, or you could have a mild infection. If you develop symptoms later, consider testing again.
How accurate is this test?
This test is highly sensitive for detecting active viral infections, especially when performed early in the illness. However, like all diagnostic tests, it may have false negatives or positives in rare cases. Results should be interpreted by a healthcare provider in the context of your symptoms and clinical situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy