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Cerebrospinal Fluid (CSF) Protein by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord) using electrophoresis, a method that separates proteins based on size and charge.

Quick summary

["Understanding your CSF protein composition can help diagnose neurological conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44876-1
Short code
FLUAV Ab CSF Ql
Synonyms
FLUAV Ab CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Electrophoresis in CSF helps identify the distribution of various protein fractions, including albumin, globulins, and other proteins. The results can show patterns that may indicate inflammation, infection, or other neurological disorders.

Why Might This Test Be Ordered?

A CSF protein electrophoresis may be recommended if you have symptoms like headaches, neurological deficits, seizures, or if tests suggest conditions such as multiple sclerosis, meningitis, or brain tumors. It can also help monitor treatment progress in certain cases.

How Is the Sample Collected?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). This involves inserting a needle into your lower back to draw fluid from the spinal canal.

What Are Common Findings?

Abnormal patterns may include elevated levels of certain proteins (e.g., oligoclonal bands in multiple sclerosis), low albumin, or high globulin levels, which can signal underlying health issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing and managing conditions affecting the central nervous system, such as infections, inflammatory diseases, or tumors. It provides insights into protein balance that can guide treatment decisions.

Short name

CSF Protein Profile

Frequently asked questions

What does a high or low protein level in CSF mean?
High protein levels in CSF can suggest conditions like meningitis, encephalitis, or certain tumors. Low protein levels may indicate conditions affecting the blood-brain barrier or certain genetic disorders.
How long does it take to get results from this test?
Results are typically available within 1 to 3 business days, depending on lab processing times. Follow-up with your healthcare provider to discuss findings.
Can lifestyle changes affect CSF protein levels?
CSF protein levels are primarily influenced by neurological conditions rather than lifestyle factors. However, always discuss any concerns with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy