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Alpha-1 Antitrypsin (Serum) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and liver damage; low levels may indicate genetic risk or underlying conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44558-5
Short code
FLUAV Ag Nph Ql IF
Synonyms
FLUAV Ag Nph Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of lung diseases (like chronic obstructive pulmonary disease or emphysema), liver problems, or if you have a family history of Alpha-1 Antitrypsin deficiency. It may also be used to monitor conditions affecting these proteins.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the blood draw if your test includes other liver function tests. Wear a loose shirt for easy access.

What Happens During the Test

A healthcare professional will insert a small needle into a vein in your arm to draw a blood sample. The process usually takes a few minutes, and you may feel a brief pinch. The blood is then sent to a lab for analysis.

What the Results Mean

Results are compared to a standard range to determine if your Alpha-1 Antitrypsin level is low, normal, or high. Very low levels may suggest a genetic disorder, while very high levels could indicate liver disease or other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low Alpha-1 Antitrypsin levels are linked to Alpha-1 Antitrypsin deficiency, a genetic condition that increases the risk of lung diseases (such as emphysema) and liver cirrhosis. High levels may be associated with chronic liver inflammation or certain inflammatory conditions.

Short name

Alpha-1 Antitrypsin (Serum)

Frequently asked questions

What causes Alpha-1 Antitrypsin levels to be low?
Low Alpha-1 Antitrypsin levels are most commonly due to a genetic mutation passed down through families. Other rare causes may include certain liver diseases or conditions that interfere with protein production.
How is Alpha-1 Antitrypsin deficiency diagnosed?
Diagnosis typically involves a blood test to measure Alpha-1 Antitrypsin levels, genetic testing to confirm mutations, and sometimes imaging or lung function tests to assess complications like lung disease.
Can lifestyle changes help if my levels are low?
While lifestyle changes alone won’t reverse low Alpha-1 Antitrypsin levels, they may help manage symptoms of lung disease. Quitting smoking, maintaining a healthy weight, and avoiding environmental irritants (like air pollution) can improve lung function and quality of life.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy