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Fluorescent Immunoassay for Anti-Fluoroquinolone Antibodies in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies your immune system produces in response to fluoroquinolone antibiotics, a class of medications used to treat bacterial infections.

Quick summary

["Helps assess immune response to fluoroquinolone exposure, potentially guiding treatment decisions or monitoring for allergic reactions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90455-7
Short code
FLUAV + FLUBV Pnl Corn/Cnjt NAA+probe
Synonyms
FLUAV + FLUBV Pnl Corn/Cnjt NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test detects specific antibodies (immunoglobulins) your body creates when exposed to fluoroquinolone antibiotics. These antibodies are part of your immune system’s defense mechanism against the medication. The presence of these antibodies can indicate prior exposure or sensitivity, which may influence future treatment plans.

Why It Might Be Ordered

Your healthcare provider may order this test if you’ve had allergic reactions, severe side effects, or persistent symptoms after taking fluoroquinolone antibiotics. It may also be used to evaluate immune response in certain clinical scenarios, such as monitoring for hypersensitivity or guiding alternative antibiotic choices.

How the Test Works

The test uses a fluorescent immunoassay method to detect antibodies in your serum or plasma. A small sample of your blood is tested in a lab where antibodies bind to labeled fluoroquinolone molecules. A fluorescent signal indicates the presence of these antibodies, helping determine your immune response level.

Preparation for the Test

No special preparation is needed for this blood test. You may have fasting instructions depending on other tests ordered together, so follow your provider’s guidance. Avoid alcohol or certain medications for 24 hours before the test if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Anti-Fluoroquinolone Antibody Test

Frequently asked questions

Why is this test important for my healthcare?
This test helps assess whether your body has developed antibodies against fluoroquinolone antibiotics, which may be relevant if you’ve experienced allergic reactions, persistent symptoms, or if alternative antibiotics are being considered. High antibody levels could suggest a prior exposure or immune response that might influence future treatment decisions.
What do my test results mean?
Results are qualitative (positive or negative) and indicate whether antibodies were detected. A positive result suggests your body recognized the fluoroquinolone, while a negative result means no detectable antibodies were found. Your doctor will interpret results in the context of your medical history and symptoms.
Can I stop taking fluoroquinolone antibiotics if I have positive antibodies?
Not necessarily. Positive antibodies may indicate an immune response but do not always mean you cannot safely use fluoroquinolones in the future. Your doctor will weigh the benefits of the medication against potential risks, such as allergic reactions or side effects, based on your overall health and medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy