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Antibody to Flavivirus Nucleocapsid Protein (IgG) - Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against the nucleocapsid protein of flaviviruses, which include viruses like dengue, yellow fever, and Zika. It helps determine if your immune system has encountered these viruses in the past.

Quick summary

["Assesses past exposure to flaviviruses through antibody detection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6634-0
Short code
FLUAV HK Ab Ser HAI-aCnc
Synonyms
FLUAV HK Ab Ser HAI-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
hai
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies specific to the nucleocapsid protein of flaviviruses. These antibodies are produced by your immune system in response to infection. The presence of these antibodies suggests prior exposure to flaviviruses, though they may not always indicate a recent or active infection.

Why It Might Be Ordered

Your healthcare provider may order this test if you have traveled to or live in an area with flavivirus risk, or if you have symptoms like fever, rash, joint pain, or neurological issues that could be linked to flavivirus infection. It can also be used for research or epidemiological studies.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The serum portion is separated and sent to the lab for analysis. This test is typically done on serum or plasma.

What to Expect Before the Test

No special preparation is needed for this test. You may eat and drink normally before your blood draw. If you are on blood-thinning medication, inform your healthcare provider beforehand.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate past exposure to flaviviruses, which can help confirm a diagnosis if symptoms are present or guide further testing. However, IgG antibodies may persist for months or years after infection, so they alone do not confirm a current infection. This test is often used alongside clinical findings and other diagnostic tools.

Short name

IgG Anti-Flavivirus Nucleocapsid

Frequently asked questions

What does a positive result mean?
A positive result means your immune system has likely encountered a flavivirus in the past, producing antibodies against its nucleocapsid protein. This does not necessarily mean you had symptoms or a confirmed illness, but it does suggest exposure.
Can this test differentiate between different flaviviruses?
No, this test only detects antibodies against the nucleocapsid protein common to many flaviviruses. Specific flaviviruses (e.g., dengue, Zika) cannot be identified with this test alone. Additional tests may be needed for precise identification.
How long do these antibodies last?
IgG antibodies against flaviviruses can remain in your system for months to years after infection. Their persistence depends on the individual and the specific virus. If you suspect recent exposure, your healthcare provider may recommend retesting or other diagnostic methods.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy