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Fluorescent Immunoassay for Anti-Nuclear Antibodies (ANA) in Serum

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies in your blood that may indicate an autoimmune condition, where your immune system mistakenly attacks healthy cells.

Quick summary

["This test helps doctors check for autoimmune diseases like lupus or rheumatoid arthritis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88600-2
Short code
FLUAV RNA Pcar Ql NAA+probe
Synonyms
FLUAV RNA Pcar Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test uses a fluorescent probe to identify specific antibodies (ANA) in your serum. These antibodies can target various parts of cells, which may signal an autoimmune response. The probe binds to these antibodies if present, making them visible under a microscope.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like joint pain, unexplained fatigue, rash, or other signs of autoimmune diseases. It can also be used as part of a routine check for conditions like lupus, Sjögren’s syndrome, or mixed connective tissue disease.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum, which is sent to the lab for testing.

What Are Common Results?

Results are typically reported as either positive or negative for ANA. A positive result means antibodies were detected, which may need further evaluation. A negative result means no antibodies were found, but other tests may still be needed to diagnose an autoimmune condition.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

ANA Fluorescent Probe Test

Frequently asked questions

What does a positive ANA test mean?
A positive ANA test means your blood contains antibodies that target healthy cells. This can be a sign of an autoimmune condition, but it doesn’t always mean you have one. Your doctor will review your symptoms, other test results, and medical history to determine the next steps.
Can a positive ANA test be false?
Yes, a positive ANA test can sometimes be false, especially if the test is not specific enough or if you have certain infections or medications. Some healthy people also test positive, so follow-up testing and evaluation are needed to understand the cause.
How often should I get this test?
Your doctor will decide how often you need this test based on your symptoms, medical history, and other test results. Some people get it once, while others may need it periodically if they have an ongoing condition or symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy