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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum. Proteins are essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses.

Quick summary

["Your blood protein levels help assess overall health and detect potential issues like malnutrition or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88194-6
Short code
FLUBV Ag Tiss Ql IF
Synonyms
FLUBV Ag Tiss Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions affecting protein production, such as liver disease, kidney disease, or certain cancers. It can also help diagnose malnutrition or monitor long-term health in chronic illnesses.

What to Expect During the Test

A small blood sample is taken from a vein, usually in your arm. You may feel a slight pinch, but it’s quick and rarely causes discomfort. No special preparation is needed unless your doctor instructs otherwise.

Possible Results and Interpretation

Results are compared to a general reference range, but individual ranges can vary by lab. Low protein levels may signal malnutrition, liver or kidney disease, or excessive protein loss. High levels could indicate dehydration, inflammation, or certain blood disorders.

Common Conditions Affecting Results

Conditions like chronic kidney disease, liver cirrhosis, or inflammatory diseases (e.g., rheumatoid arthritis) can alter protein levels. Severe burns, dehydration, or certain medications may also impact results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low total protein can result from conditions that reduce protein synthesis (e.g., liver disease), increase protein loss (e.g., kidney disease), or poor nutrition. It may also occur in severe infections, burns, or during certain medications.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab and insurance. Some labs may provide preliminary results sooner, but final reports are usually detailed and reviewed by a healthcare provider.
Can diet affect my protein test results?
Yes, diet can influence protein levels. High-protein diets or malnutrition may temporarily alter results, while chronic deficiencies (e.g., from poor absorption) can lead to sustained low protein. Your doctor may recommend dietary adjustments if needed, especially if underlying conditions like kidney disease are present.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy