Skip to content

Vitamin B12 (Serum or Plasma Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of vitamin B12 in your blood. Vitamin B12 is essential for nerve function, red blood cell production, and DNA synthesis.

Quick summary

["Check your vitamin B12 levels to ensure proper health and prevent deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
85821-7
Short code
FLUBV Vic Ag Islt Ql HAI
Synonyms
FLUBV Vic Ag Islt Ql HAI
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
1.5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
hai
CPT
83002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like fatigue, numbness, tingling in the hands or feet, weakness, or memory problems. It could also be done to diagnose or monitor conditions like pernicious anemia, vitamin B12 deficiency, or other blood disorders.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if a blood draw is required. Bring any medications you’re currently taking to your appointment.

How the Test Is Performed

A healthcare provider will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but it usually doesn’t cause discomfort. The blood sample is then sent to a lab for analysis.

What the Results Mean

Low levels of vitamin B12 may indicate deficiency, which can lead to health problems over time. High levels might suggest certain medical conditions or medications affecting absorption. Your doctor will interpret the results in the context of your symptoms and medical history.

Reference range

Follicular: 1.5-9.0 mIU/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Vitamin B12 deficiency can cause serious health issues, including anemia, nerve damage, and cognitive problems. Early detection and treatment can prevent long-term complications. Your doctor may recommend follow-up tests or treatments like vitamin B12 supplements or injections if needed.

Short name

Vitamin B12 Level

Frequently asked questions

What causes low vitamin B12 levels?
Low vitamin B12 levels can result from poor diet (e.g., vegan/vegetarian diets), conditions affecting absorption (like pernicious anemia or celiac disease), certain medications, or chronic illnesses. Symptoms may develop gradually, so regular monitoring is important.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your doctor will discuss the findings with you during your follow-up visit.
Can I take vitamin B12 supplements before the test?
It’s best to avoid taking vitamin B12 supplements or high-dose multivitamins 2–3 weeks before testing unless instructed by your doctor. This ensures accurate results. Always follow your healthcare provider’s guidance.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy