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Total Monoclonal Immunoglobulin (Ig) Levels in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a single type of antibody (immunoglobulin) produced in large quantities by a specific type of immune cell, often seen in conditions like multiple myeloma or other monoclonal gammopathies.

Quick summary

["This test helps identify abnormal antibody production that may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39600-2
Short code
F moniliforme IgE/IgE total %
Synonyms
F moniliforme IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like unexplained fatigue, frequent infections, bone pain, or kidney issues. It could also be part of a routine check for conditions affecting your immune system or blood cells.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes about 15 minutes. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

High levels of monoclonal immunoglobulins may indicate conditions like multiple myeloma, where the body produces too many identical antibodies. Low or normal levels are less concerning but can still be monitored if you have a known condition.

Common Conditions Monitored

This test is often used to diagnose or monitor multiple myeloma, Waldenström macroglobulinemia, and other monoclonal gammopathies. It may also help track treatment progress or response to therapy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Monoclonal Protein

Frequently asked questions

What causes abnormal monoclonal immunoglobulin levels?
Abnormal levels are most commonly linked to conditions like multiple myeloma or other monoclonal gammopathies. Rarely, they can appear in people with certain autoimmune diseases or after exposure to certain medications.
How often should this test be repeated?
Your doctor will determine how often you need retesting based on your symptoms, diagnosis, and treatment plan. Some patients with known conditions may need tests every few months or annually.
Can lifestyle changes affect this test result?
While diet and exercise generally don’t directly impact immunoglobulin levels, managing chronic conditions (like infections or inflammation) can indirectly affect test results. Always follow your doctor’s advice for lifestyle adjustments related to your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy