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Cerebrospinal Fluid (CSF) Free Monoclonal Proteins (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of abnormal proteins found in your cerebrospinal fluid, which may indicate conditions like multiple myeloma or other monoclonal gammopathies.

Quick summary

["Abnormal proteins in CSF can signal serious neurological or blood-related disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58748-5
Short code
fMR Brain
Synonyms
fMR Brain
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mr-functional
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like unexplained headaches, neurological issues, or signs of a blood disorder. It helps diagnose conditions affecting the central nervous system or blood cells by analyzing proteins in the fluid surrounding your brain and spinal cord.

What to Expect Before the Test

No special preparation is needed, but you may be asked to lie down on an examination table for a lumbar puncture (spinal tap). This procedure involves inserting a needle into your lower back to collect CSF. You may feel pressure or discomfort, but it’s usually brief.

What the Results Mean

Results show the concentration of monoclonal proteins in your CSF. Elevated levels may suggest conditions like multiple myeloma, lymphoma, or other monoclonal gammopathies. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Linked to Abnormal Results

High levels of monoclonal proteins in CSF can be linked to blood disorders (e.g., multiple myeloma), certain infections, or inflammatory diseases. Low or normal levels may rule out these conditions but don’t rule out others.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Monoclonal Proteins

Frequently asked questions

What does a positive result mean for my health?
A positive result (elevated monoclonal proteins) may indicate a blood disorder like multiple myeloma or lymphoma. Your doctor will discuss further testing or treatment options based on the results and your symptoms.
Can I eat or drink before this test?
You can eat and drink normally before the test, as no special diet is required. However, inform your doctor if you’re on blood thinners or have a history of bleeding disorders, as this may affect the procedure.
How long will it take to get my results?
Results are typically available within a few days to a week, depending on lab processing times. Your doctor will contact you with the final report once reviewed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy