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Alpha-Fodrin IgA Antibody, Serum/Plasma — Immunoassay, Arbitrary Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures IgA antibodies against alpha-fodrin in serum or plasma. This test may help support an evaluation for certain autoimmune conditions, including Sjögren syndrome.

Quick summary

["An elevated alpha-fodrin IgA result can occur with autoimmune disease but must be interpreted alongside symptoms and other laboratory findings."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96918-8
Short code
Fodrin alpha IgA SerPl IA-aCnc
Synonyms
Fodrin alpha IgA SerPl IA-aCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
84075
SNOMED
27550007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures IgA antibodies directed against alpha-fodrin, a protein found in cells throughout the body. The result is reported as an arbitrary concentration, which is a lab-specific unit used for comparison with prior results from the same laboratory.

Why might I need this test?

Alpha-fodrin IgA antibodies may be measured as an additional test when an autoimmune condition, particularly Sjögren syndrome, is being evaluated. It is generally interpreted together with symptoms, examination findings, and other antibody tests rather than used alone to make a diagnosis.

How is the test performed?

A blood sample is collected, and serum or plasma is tested using an immunoassay to detect alpha-fodrin IgA antibodies. No radioactive substances are involved, and the laboratory usually reports the measurement in arbitrary units.

How do I prepare for the test?

Fasting is generally not required for this test. Tell your clinician if you have an autoimmune condition, are receiving immune-related treatment, or have recently had an infection, because these factors may affect interpretation.

Reference range

Adult: 44-147 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-Fodrin IgA Antibody

Frequently asked questions

Does a positive alpha-fodrin IgA result mean I have Sjögren syndrome?
No. This antibody may be present in Sjögren syndrome, but it can also occur in other conditions and in some healthy people, so the result must be interpreted with other clinical and laboratory evidence.
What does an arbitrary concentration mean?
It is a unit used to report a measured substance when there is no broadly standardized unit. Results are most useful when compared with the reference interval and previous results from the same laboratory.
Is this the same as an ANA or rheumatoid factor test?
No. This test detects a specific type of antibody against alpha-fodrin, while ANA and rheumatoid factor tests detect different antibodies or immune markers. They may be performed together as part of an autoimmune evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy