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Folate in Blood (Serum or Plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of folate, a type of B vitamin, in your blood. Folate helps your body make healthy red blood cells and DNA.

Quick summary

["Folate levels help check if you have a vitamin deficiency that could affect your health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
25415-1
Short code
Folate Bld-sCnc
Synonyms
Folate Bld-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
2.7
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, weakness, or unusual bleeding. It’s also used to screen for conditions like anemia or to monitor folate supplements.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on folate supplements, let your doctor know.

What the Results Mean

Lower than normal levels may indicate a deficiency, which can be caused by poor diet, certain medications, or malabsorption issues. Higher levels might suggest folate overload or recent supplements.

Common Conditions Linked to Folate Levels

Low folate can lead to megaloblastic anemia (large, immature red blood cells) or neural tube defects in pregnancy. High levels may mask vitamin B12 deficiency, which can cause nerve damage.

Reference range

NCBI: Folate 2.7-17.0 ng/mLN/A

Specimen: whole-blood

Fasting for 8-12 hours preferred for some tests. Inform about supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Folate plays a critical role in red blood cell production and DNA synthesis. Deficiencies are common in people with alcoholism, poor diets, or conditions like celiac disease.

Short name

Folate Level

Frequently asked questions

What causes low folate levels?
Low folate can result from poor diet (low intake of leafy greens, beans, or fortified foods), certain medications (like anticonvulsants), alcohol use, or conditions that affect nutrient absorption.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab. Follow-up with your doctor if you have questions about your results.
Can folate levels change with diet?
Yes, eating foods rich in folate (like spinach, lentils, or fortified cereals) can raise your levels. Avoiding alcohol and taking supplements (if prescribed) may also help maintain balance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy