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Folate in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of folate, a B vitamin essential for red blood cell production and DNA synthesis, in your blood serum.

Quick summary

["Folate levels help assess vitamin deficiency and support overall health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2284-8
Short code
Folate SerPl-mCnc
Synonyms
Folate SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2.7
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for folate deficiency, which can cause anemia, neurological issues, or other health problems. It’s often done if you have symptoms like fatigue, weakness, or unusual bleeding. Folate is also important during pregnancy to prevent birth defects.

What Does a Low or High Level Mean?

Low folate levels may indicate poor nutrition, malabsorption issues, or certain medications that deplete the vitamin. High levels might be due to overconsumption of folate supplements or foods rich in folate, though this is less common.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion is separated and analyzed to measure folate concentration using a specialized laboratory method.

What Are Common Causes of Folate Deficiency?

Folate deficiency can result from inadequate diet (low intake of leafy greens, fortified grains), alcohol use, certain medications (like anticonvulsants), or conditions that impair nutrient absorption (e.g., celiac disease).

Reference range

NCBI: Folate 2.7-17.0 ng/mLN/A

Specimen: serum

Fasting for 8-12 hours preferred for some tests. Inform about supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Folate is critical for cell growth and repair. Deficiencies can lead to anemia, increased risk of certain cancers, or complications in pregnancy. Monitoring folate levels helps prevent long-term health issues and guides treatment plans for deficiencies.

Short name

Serum Folate

Frequently asked questions

What symptoms might indicate a folate deficiency?
Symptoms may include fatigue, weakness, pale or jaundiced skin, shortness of breath, neurological issues like numbness or tingling, or frequent infections. However, some people may not show symptoms until deficiency is severe.
How can I maintain healthy folate levels?
Eat a balanced diet rich in folate, such as leafy greens, beans, fortified cereals, and citrus fruits. If you have a deficiency or risk factors, your doctor may recommend folate supplements. Avoid excessive alcohol use, as it can interfere with folate absorption.
Can folate levels change with diet or supplements?
Yes, dietary changes or supplements can significantly affect folate levels. If you’re taking folate supplements, follow your doctor’s guidance to avoid excessive intake, as very high doses may mask vitamin B12 deficiency symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy