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Serum Folate Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of folate, a B vitamin important for red blood cell production and DNA synthesis, in your blood serum.

Quick summary

["Folate helps prevent birth defects and supports overall cell function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
35210-4
Short code
Folate SerPl-msCnc
Synonyms
Folate SerPl-msCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
2.7
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for folate deficiency, which can cause anemia, neurological issues, or increased risk of certain cancers. It’s also used in pregnancy to prevent neural tube defects in the baby.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a fasting protocol. Bring any medications you’re taking to your appointment.

How the Test Works

A blood sample is taken from a vein in your arm. The lab analyzes the serum portion for folate levels using a sensitive immunoassay method.

What the Results Mean

Results help determine if your folate levels are low, normal, or high. Low levels may require dietary changes or supplements, while high levels could signal underlying conditions like liver disease.

Reference range

NCBI: Folate 2.7-17.0 ng/mLN/A

Specimen: serum

Fasting for 8-12 hours preferred for some tests. Inform about supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Folate (Serum)

Frequently asked questions

What causes low folate levels?
Common causes include poor diet (low folate intake), alcohol use, certain medications (e.g., anticonvulsants), or malabsorption disorders like celiac disease.
How is folate deficiency treated?
Treatment often involves dietary changes (leafy greens, fortified foods) or oral supplements under medical supervision. Severe cases may require intravenous folate.
Can folate levels be affected by medications?
Yes, some medications (e.g., antacids, certain antibiotics) can interfere with folate absorption or metabolism. Always discuss supplements with your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy