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Folates and Methionine Metabolism Profile in Cerebrospinal Fluid (CSF)

Published: August 9, 2026Updated: August 17, 2026

This test measures levels of folate and related metabolites in your cerebrospinal fluid to assess how these nutrients are involved in brain chemistry and cell function.

Quick summary

["Your CSF folate and methionine levels help evaluate potential neurological or metabolic concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
79572-4
Short code
Folate + Tryp + Metabs Pnl CSF
Synonyms
Folate + Tryp + Metabs Pnl CSF
Category
coagulation
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
2.7
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test includes measurements of folate (a B vitamin) and its active forms, as well as methionine—a key amino acid involved in cell metabolism. These analytes are analyzed to check for imbalances that could affect brain health or neurological function.

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like memory issues, mood changes, or neurological problems that could be linked to folate or methionine deficiencies. It’s also used in research or specialized cases where CSF nutrient metabolism is a focus.

How Is the Sample Collected?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). This involves inserting a needle into your lower back to draw fluid from the spinal canal.

What Should You Expect Before the Test?

Prepare by staying hydrated but avoid caffeine or alcohol for 24 hours before the procedure. Wear comfortable clothing and bring any necessary medications with you.

Reference range

NCBI: Folate 2.7-17.0 ng/mLN/A

Specimen: csf

Fasting for 8-12 hours preferred for some tests. Inform about supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Folates & Methionine CSF Profile

Frequently asked questions

How Might Results Affect My Care?
Low levels of folate or methionine in CSF could indicate conditions like neurological disorders, metabolic disorders, or deficiencies that require medical attention. High levels might suggest certain genetic or metabolic conditions that need further evaluation.
What Are Common Reasons for Abnormal Results?
Abnormal results may signal underlying issues such as inherited metabolic disorders, neurological diseases, or conditions affecting nutrient absorption. Your provider will discuss these findings with you during your follow-up.
How Long Does It Take to Get Results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your healthcare provider to discuss findings and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy