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Serum/plasma free total protein concentration (24-hour urinary collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein that appears in your urine over a full day. It helps assess kidney function and detect protein loss, which can signal conditions like kidney disease or other health issues.

Quick summary

["This test helps monitor kidney health and identify protein loss in urine over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111902-3
Short code
Frst apprch mthd Blry tr Endscpy
Synonyms
Frst apprch mthd Blry tr Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect kidney problems, such as nephrotic syndrome, glomerulonephritis, or other conditions causing abnormal protein excretion. It can also be used to monitor chronic kidney disease or track responses to treatments.

What to Expect Before the Test

You’ll need to collect all urine for 24 hours, typically starting after midnight on one day and ending the same time the next day. Drink plenty of water to ensure adequate urine volume. Avoid certain medications or foods that might interfere with results (consult your doctor for specifics).

How the Test Works

Your urine sample is analyzed to measure the total protein content. The test quantifies how much protein is excreted daily, which is compared to standard reference values to identify abnormalities.

Possible Results and What They Mean

Higher-than-normal protein levels in urine may indicate kidney damage, inflammation, or other systemic conditions. Lower-than-normal levels are less common but could suggest dehydration or certain metabolic disorders. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

24-Hour Urinary Free Protein

Frequently asked questions

What causes elevated protein in urine?
Elevated protein in urine can result from kidney diseases (e.g., glomerulonephritis), diabetes, infections, or conditions like multiple myeloma. It may also appear in response to trauma, high blood pressure, or certain medications.
What if my protein levels are normal?
Normal results don’t rule out kidney issues entirely. Some kidney problems cause intermittent protein loss, so follow-up tests or repeat measurements may be needed. Regular monitoring is important if you have risk factors like diabetes or high blood pressure.
Can diet affect this test?
Yes, certain foods (e.g., high-protein diets) or medications (e.g., NSAIDs) can temporarily alter protein excretion. Your doctor will provide specific dietary or medication restrictions to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy