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Serum Fructosamine

Published: August 9, 2026Updated: August 16, 2026

This test measures the average blood sugar levels over the past 2–3 weeks by tracking glycated proteins, reflecting how your body has managed glucose over time.

Quick summary

["Helps assess long-term blood sugar control in diabetes or prediabetes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10574-2
Short code
Fructose Smn-sCnc
Synonyms
Fructose Smn-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Unlike hemoglobin A1c, which measures blood sugar over roughly 3 months, fructosamine gives a snapshot of recent glucose exposure. It’s useful for monitoring treatment in people with diabetes who may have frequent blood sugar fluctuations or certain blood disorders that affect hemoglobin stability.

How It Works

Fructosamine levels rise when blood sugar is consistently high because glucose attaches to proteins in your blood. The test detects these glycated proteins using an immunoassay method, providing a direct measure of your body’s average glucose exposure over a shorter timeframe.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample drawn from a vein, similar to other routine blood tests. Results are typically reported in mass concentration units (mg/dL or µmol/L).

What the Results Mean

Higher fructosamine levels often indicate poor blood sugar control, particularly in people with diabetes. Lower levels may suggest consistently lower glucose levels, though this isn’t always the case. Always discuss results with your healthcare provider to interpret them in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Fructosamine Level

Frequently asked questions

How often should I get this test?
Your healthcare provider will determine the frequency based on your medical history, diabetes management goals, and other health factors. For example, people with diabetes may test more often if they’re adjusting medications or experiencing symptoms like frequent infections or fatigue.
Can fructosamine replace hemoglobin A1c?
No, they serve different purposes. Hemoglobin A1c is generally preferred for long-term diabetes monitoring because it’s more stable and less affected by recent blood sugar spikes. Fructosamine is useful when you need a shorter-term view of glucose control, especially in certain conditions.
What causes fructosamine levels to change?
Several factors can influence fructosamine levels, including recent blood sugar trends, certain medications (like some steroids), liver or kidney disease, and conditions that affect protein synthesis or breakdown. Always ask your provider about potential influences on your specific results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy