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Serum or plasma mass concentration of protein (e.g., albumin, globulin, or total protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes important proteins like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Total protein levels can indicate overall health, hydration status, or potential protein-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30226-5
Short code
FSP PPP-mCnc
Synonyms
FSP PPP-mCnc
Category
coagulation
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Blood Health

Protein is vital for many bodily functions, including keeping tissues strong, aiding in wound healing, and helping your immune system fight infections. Low or high protein levels may signal underlying health concerns, such as kidney disease, liver issues, or malnutrition.

What to Expect During the Test

A simple blood draw is typically used to collect the sample. The test measures the total protein content in your serum or plasma, which is then analyzed in a lab.

Common Conditions Monitored

Doctors may order this test to check for conditions like malnutrition, kidney disease, liver problems, or dehydration. It can also help assess protein loss due to conditions like nephrotic syndrome or severe burns.

What Your Results Might Mean

Results are usually reported as a single value representing the total protein concentration. While reference ranges vary by lab, very low levels may suggest protein loss or poor nutrition, while very high levels could indicate conditions like multiple myeloma or dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

If your doctor orders this test, they may be monitoring for conditions like chronic kidney disease, liver disease, or malnutrition. Persistently abnormal results could prompt further testing or adjustments to your treatment plan.
This test is often used as a general health check or part of a broader evaluation for conditions affecting protein metabolism.
How often should I get this test?
The frequency depends on your health status. Doctors may recommend it annually for routine check-ups or more often if you have a known condition affecting protein levels.
Can diet affect my protein test results?
Yes, diet can influence protein levels. High-protein diets may temporarily raise results, while poor nutrition or excessive fluid loss can lower them. Always discuss your diet with your healthcare provider before or after testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy