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Serum Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the types and amounts of proteins in your blood, separated by size and charge, to help identify abnormalities in protein distribution.

Quick summary

["This test helps diagnose conditions like multiple myeloma, liver disease, or kidney problems by showing unusual protein patterns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13054-2
Short code
FSP Ur-aCnc
Synonyms
FSP Ur-aCnc
Category
coagulation
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test separates blood proteins into five main zones: albumin, alpha-1 globulins, alpha-2 globulins, beta globulins, and gamma globulins. Each zone contains different proteins that help your body function, and their proportions can indicate health issues.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions like multiple myeloma, lymphoma, liver disease, or kidney disease. It can also help monitor certain treatments.

Common Conditions Monitored

This test is often used to detect abnormal protein levels that may suggest conditions such as monoclonal gammopathy (like multiple myeloma), chronic liver disease, or severe kidney problems. It can also help track how well certain treatments are working.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is then processed and mixed with a special solution. A thin strip of paper is placed in the solution, and proteins move through it based on their size and charge. The strip is then analyzed to see how proteins have separated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Qualitative Serum Protein Electrophoresis

Frequently asked questions

What Are My Results Meaning?
Results show abnormal patterns of proteins, such as spikes or bands that appear outside the normal zones. These can indicate conditions like monoclonal gammopathy (where there’s an abnormal protein produced by cancerous plasma cells), liver disease (where protein production is impaired), or kidney problems (where proteins may leak into urine). Always discuss your results with your healthcare provider.
How Often Should I Get This Test?
The frequency depends on your health condition and treatment plan. If you have a chronic illness like multiple myeloma, your doctor may recommend regular follow-ups. If this is a one-time screening test, it may not be repeated unless symptoms or test results suggest further evaluation.
What Can I Do to Prepare?
No special preparation is usually needed, but avoid eating or drinking anything (except water) for a few hours before the test if instructed. Wear comfortable clothing and let your healthcare provider know about any medications you’re taking or health conditions you have to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy