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Folate and Vitamin B12 Serum Levels (Qualitative Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures your levels of folate (a B vitamin) and vitamin B12 (cobalamin) in your blood serum. Both are essential for red blood cell production, nerve function, and DNA synthesis.

Quick summary

["Checks if your body has enough of these important vitamins for proper health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109937-3
Short code
F tular IgG Msmt Ser
Synonyms
F tular IgG Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Folate and vitamin B12 are critical for preventing birth defects, maintaining healthy blood cells, and supporting nerve health. Low levels can cause anemia, nerve damage, or other serious conditions.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before your blood draw if your doctor recommends it. Bring your lab slip and wear a loose shirt for easy access.

What Happens During the Test

A healthcare provider will draw blood from a vein in your arm. The process usually takes a few minutes, and you may feel a brief pinch. The blood is then sent to a lab for analysis.

What the Results Mean

Results are qualitative (screening only) and indicate whether your levels are low, normal, or high. Your doctor will interpret these results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Folate & B12 Screen (Serum)

Frequently asked questions

Is folate or vitamin B12 deficiency common?
Yes, especially in people with poor diets, certain medical conditions, or those who take medications that interfere with absorption. Symptoms may include fatigue, tingling in hands/feet, or unusual weakness.
Can diet or supplements help if levels are low?
Yes! Folate-rich foods include leafy greens, beans, and fortified cereals. Vitamin B12 is found in animal products like meat, eggs, and dairy. Your doctor may recommend supplements if needed.
How often should I get this test?
Your doctor will determine frequency based on your health status, risk factors, or symptoms. Regular checks may be advised for pregnant women, people with chronic illnesses, or those on certain medications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy