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Hemoglobin A1c (HbA1c) with 24-hour urine collection for creatinine clearance calculation

Published: August 9, 2026Updated: August 16, 2026

This test measures your average blood sugar levels over the past 2–3 months and evaluates how well your kidneys filter waste through a 24-hour urine sample.

Quick summary

Helps track diabetes management and kidney function together.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
64301-5
Short code
FULLTIMEDIETITIANSTAFFPOSITIONSFILLEDATENDOFPERIOD
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters for Diabetes Care

HbA1c reflects your blood sugar control over time, while creatinine clearance assesses kidney function. Together, they provide a fuller picture of your health, especially if you have diabetes or kidney concerns.

How the Test Works

Your blood is tested for HbA1c (a protein linked to red blood cells that carries hemoglobin), and a 24-hour urine sample is analyzed for creatinine (a waste product from muscle metabolism). The urine test helps calculate how well your kidneys filter blood.

What to Expect Before the Test

For the urine test, collect all urine for a full 24-hour period (typically from one morning to the next morning). For the blood test, you’ll have a simple fingerstick or vein draw. Follow any specific instructions your provider gives you, such as fasting or avoiding certain foods.

Common Results and What They Mean

HbA1c results alone show long-term blood sugar trends, while creatinine clearance results show kidney function. Your provider will interpret these together to guide treatment, such as adjusting diabetes medications or monitoring kidney health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HbA1c + CrCl (24h urine)

Frequently asked questions

How often should I get this test?
Your provider will determine frequency based on your diabetes management plan, kidney health, and overall medical needs. Typically, HbA1c is checked every 3–6 months, and kidney function tests may be done more often if you have diabetes or kidney issues.
What does a high creatinine clearance mean?
A higher creatinine clearance suggests your kidneys are filtering waste more efficiently. However, this alone doesn’t indicate kidney disease—your provider will review it alongside other tests (like urine protein or blood tests) to assess kidney health.
Can I eat or drink anything before the urine test?
Yes, you can eat and drink normally for the urine test, but you should collect all urine for the full 24-hour period. For the blood test, fasting may be required—always follow your provider’s specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy