Complete Blood Count (CBC) with Differential
This test measures the types and amounts of cells in your blood, including red blood cells, white blood cells, and platelets, along with the breakdown of white blood cells into specific types (differential).
Understanding your blood cell counts helps doctors diagnose and monitor conditions like anemia, infections, or blood disorders.
Key facts at a glance
- LOINC
- 64310-6
- Short code
- FULLTIMELICENSEDPRACTICALNURSEANDLICENSEDVOCATIONALNURSESTAFFPOSITIONS
- Synonyms
- —
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 17
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why a CBC with Differential is Done
A CBC with Differential is often ordered to check for signs of infections, anemia, blood disorders (such as leukemia), or other health issues. It may also be used during routine check-ups, before surgeries, or to monitor chronic conditions like kidney disease or autoimmune disorders.
What the Test Measures
The test measures several components: - **Red Blood Cells (RBCs):** Carry oxygen to your body’s tissues. - **White Blood Cells (WBCs):** Fight infections and help your body fight illness. - **Platelets:** Help your blood clot to prevent excessive bleeding. - **Hemoglobin (Hb):** The protein in RBCs that carries oxygen. - **Hematocrit (Hct):** The proportion of blood volume made up of RBCs. - **Differential Count:** The percentage of each type of white blood cell (neutrophils, lymphocytes, monocytes, eosinophils, basophils).
What You Should Expect
A simple blood draw is typically done from a vein in your arm. The process is quick and usually painless. You may feel a slight pinch or sting, but most people tolerate it well. No special preparation is needed, but let your doctor or nurse know if you’re on blood-thinning medication or have a history of bleeding issues.
Possible Results and Their Meaning
Results can vary widely based on your health, age, and other factors. Low or high counts of RBCs, WBCs, or platelets may indicate underlying health concerns. For example: - Low RBCs or hemoglobin could signal anemia. - High or low WBC counts might suggest infections or immune system issues. - Abnormal differential counts could point to infections, inflammation, or other conditions.
Reference range
NCBI: NSE 0-17 ng/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
CBC with Differential
Frequently asked questions
What does a CBC with Differential tell me about my health?
How often should I get this test?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy