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Complete Blood Count (CBC) with Differential

Published: August 9, 2026Updated: August 17, 2026

This test measures the types and amounts of cells in your blood, including red blood cells, white blood cells, and platelets, along with the breakdown of white blood cells into specific types (differential).

Quick summary

Understanding your blood cell counts helps doctors diagnose and monitor conditions like anemia, infections, or blood disorders.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
64310-6
Short code
FULLTIMELICENSEDPRACTICALNURSEANDLICENSEDVOCATIONALNURSESTAFFPOSITIONS
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why a CBC with Differential is Done

A CBC with Differential is often ordered to check for signs of infections, anemia, blood disorders (such as leukemia), or other health issues. It may also be used during routine check-ups, before surgeries, or to monitor chronic conditions like kidney disease or autoimmune disorders.

What the Test Measures

The test measures several components: - **Red Blood Cells (RBCs):** Carry oxygen to your body’s tissues. - **White Blood Cells (WBCs):** Fight infections and help your body fight illness. - **Platelets:** Help your blood clot to prevent excessive bleeding. - **Hemoglobin (Hb):** The protein in RBCs that carries oxygen. - **Hematocrit (Hct):** The proportion of blood volume made up of RBCs. - **Differential Count:** The percentage of each type of white blood cell (neutrophils, lymphocytes, monocytes, eosinophils, basophils).

What You Should Expect

A simple blood draw is typically done from a vein in your arm. The process is quick and usually painless. You may feel a slight pinch or sting, but most people tolerate it well. No special preparation is needed, but let your doctor or nurse know if you’re on blood-thinning medication or have a history of bleeding issues.

Possible Results and Their Meaning

Results can vary widely based on your health, age, and other factors. Low or high counts of RBCs, WBCs, or platelets may indicate underlying health concerns. For example: - Low RBCs or hemoglobin could signal anemia. - High or low WBC counts might suggest infections or immune system issues. - Abnormal differential counts could point to infections, inflammation, or other conditions.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CBC with Differential

Frequently asked questions

What does a CBC with Differential tell me about my health?
It provides a snapshot of your blood’s health, helping identify issues with red blood cells (like anemia), white blood cells (like infections or inflammation), or platelets (like bleeding disorders). Your doctor will interpret the results in the context of your symptoms and medical history.
How often should I get this test?
The frequency depends on your health needs. Routine adults may get a baseline CBC every few years, while those with chronic conditions (like diabetes or heart disease) might have it more often. Your doctor will determine the best schedule for you.
Can I eat or drink before this test?
No special diet is needed for a CBC. You can eat and drink normally before the test, but let your healthcare provider know if you’re taking blood-thinning medications or have any allergies to blood collection supplies.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy