Genetic Analysis for Fusion Gene Arrangements in Blood (Next-Generation Sequencing)
This test checks for specific genetic rearrangements—fusions—between genes in your blood cells that may be linked to certain cancers or blood disorders.
["Helps identify genetic changes that could influence cancer treatment options or monitor disease progression."]
Key facts at a glance
- LOINC
- 101383-8
- Short code
- FUS gene rearrangements Bld/T FISH
- Synonyms
- FUS gene rearrangements Bld/T FISH
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- fish
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have a suspected blood cancer (e.g., leukemia, lymphoma) or other conditions where fusion genes are known to play a role, such as certain types of solid tumors. It may also be used to guide personalized treatment plans.
How the Test Works
A small blood sample is collected and analyzed using advanced sequencing technology to detect abnormal gene fusions. This process identifies specific DNA sequences that have been rearranged, often involving genes like *BCR-ABL* or *EML4-ALK*, which are common in certain cancers.
Sample Collection and Preparation
Whole blood is drawn from a vein, typically in the arm. The sample is processed and sent to a lab for genetic sequencing. Results are usually available within 1–2 weeks, depending on lab workflows.
What the Results Mean
Positive results indicate the presence of a known fusion gene, which may confirm a diagnosis or help tailor treatment (e.g., targeted therapies like tyrosine kinase inhibitors). Negative results mean no detectable fusion was found in this sample.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Fusion Gene Testing (NGS)
Frequently asked questions
Genetic fusion genes are often associated with aggressive cancers or resistance to standard treatments. Identifying them allows doctors to choose more precise therapies, such as drugs that target specific gene mutations.
How long will I need to wait for results?
What if my test comes back positive for a fusion gene?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy