Glucose-6-Phosphate Dehydrogenase (G6PD) Activity in Red Blood Cells (RBCs)

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, jaundice (yellowing of skin/eyes), or frequent episodes of hemolysis (destruction of red blood cells). It’s also used to screen for or confirm G6PD deficiency, which can make you more sensitive to certain medications or infections.

What Does a Low or High Result Mean?

Low levels of G6PD activity may indicate G6PD deficiency, a genetic condition that increases your risk of red blood cell damage when exposed to certain triggers (like certain foods, medications, or infections). High levels are less common but could suggest other underlying conditions that need further evaluation.

How Is This Test Performed?

A small blood sample is taken from a vein in your arm. The blood is then processed to isolate red blood cells, and the enzyme activity is measured using specialized laboratory techniques.

What Are Common Triggers for G6PD Deficiency?

G6PD deficiency can be triggered by certain foods (e.g., fava beans), medications (e.g., antimalarials, sulfonamides), infections, or oxidative stress from illness. These triggers can cause red blood cells to break down more easily, leading to symptoms like fatigue or jaundice.