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24-Hour Urinary Gamma-Aminobutyric Acid (GABA) Excretion Rate

Published: August 9, 2026Updated: August 16, 2026

This test measures how much of the brain chemical GABA is excreted in your urine over a full day. GABA is a neurotransmitter that helps regulate brain activity and may be involved in conditions like epilepsy or anxiety.

Quick summary

["Assessing GABA levels in urine can help diagnose or monitor certain neurological or metabolic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6882-5
Short code
GABA 24h Ur-mRate
Synonyms
GABA 24h Ur-mRate
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or a suspected condition linked to GABA dysfunction, such as seizures, neurological disorders, or metabolic issues. It could also be part of a broader evaluation for epilepsy, brain injury, or other neurological concerns.

How the Test Works

You’ll collect all your urine for a full 24-hour period in a special container. The collected urine is then sent to a lab for analysis to determine the amount of GABA present over that time.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to drink extra fluids to ensure adequate urine production. Avoid certain medications or supplements that might affect GABA levels before testing, as advised by your provider.

What to Expect During the Test

You’ll provide a full 24-hour urine sample by collecting all urine produced in a sealed container. This is usually done at home with instructions from your healthcare team.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test helps evaluate GABA metabolism, which can be important in diagnosing conditions like epilepsy, mitochondrial disorders, or other neurological or metabolic syndromes. Abnormal results may indicate an imbalance in GABA production or excretion, guiding further medical evaluation.

Short name

GABA Urine Rate (24h)

Frequently asked questions

What does a low or high GABA urine rate mean?
Low levels might suggest issues with GABA synthesis, storage, or excretion, potentially linked to neurological disorders or metabolic problems. High levels could indicate overproduction or reduced clearance, which may also relate to certain genetic or neurological conditions. Your provider will interpret results in the context of your overall health and symptoms.
How often is this test repeated?
The frequency depends on your diagnosis and treatment plan. Some patients may need repeated testing to monitor changes in GABA levels over time, especially if they’re being treated for conditions like epilepsy or other neurological disorders.
Can I take medications before this test?
Some medications or supplements may affect GABA levels. Always follow your healthcare provider’s instructions—avoid any medications unless specifically cleared by them to prevent interfering with the test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy