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Gamma-Aminobutyric Acid (GABA) in Plasma/Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of gamma-aminobutyric acid (GABA), a key neurotransmitter in the brain that helps regulate nerve cell activity.

Quick summary

["GABA levels may be checked to assess brain function or investigate neurological symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26804-5
Short code
GABA 24h Ur Ql
Synonyms
GABA 24h Ur Ql
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like seizures, anxiety, or movement disorders. It could also be part of a broader evaluation for conditions affecting brain chemistry or metabolic processes.

What to Expect Before the Test

No special preparation is typically needed. If blood is drawn, you may experience a slight pinch, but it usually doesn’t cause long-term discomfort. If urine is collected, follow any instructions to ensure accurate results.

What the Results Mean

GABA levels can vary based on health, diet, medications, and other factors. Abnormal results may prompt further testing or evaluation by a specialist, such as a neurologist or psychiatrist.

Common Conditions Monitored

GABA levels are sometimes checked in people with epilepsy, autism spectrum disorder, or other neurological conditions where GABA’s role is suspected. It may also be part of research or specialized diagnostic protocols.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

GABA is the primary inhibitory neurotransmitter in the brain, helping to calm nerve activity. Low GABA levels may be linked to conditions like epilepsy or anxiety, while high levels could indicate metabolic disorders or certain brain injuries. However, GABA testing alone is rarely definitive—results are often interpreted alongside clinical findings and other tests.

Short name

GABA Level

Frequently asked questions

What does a low or high GABA level indicate?
A low GABA level might suggest neurological conditions affecting its production or function, but it’s not always conclusive. High levels could indicate metabolic issues or rare genetic disorders. Your doctor will discuss these findings with you.
How is GABA tested in the blood or urine?
The test measures GABA concentration in either plasma/serum (blood) or urine, depending on the clinical question. Blood tests are often drawn from a vein, while urine tests involve collecting a sample over a specified period (e.g., 24 hours).
Can diet or medications affect GABA levels?
Yes. Certain foods (like those rich in magnesium or tryptophan), supplements, or medications (e.g., antidepressants) can influence GABA levels. Avoiding alcohol or certain medications for a few days before testing may help ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy