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Gamma-Aminobutyric Acid (GABA) in Cerebrospinal Fluid

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of gamma-aminobutyric acid (GABA), a key neurotransmitter in your brain and spinal cord, found in cerebrospinal fluid (CSF). It may help assess neurological function or identify conditions affecting GABA levels.

Quick summary

["GABA is vital for calming nerve activity; abnormal levels could signal neurological disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101870-4
Short code
GABAAR IgG Titr CSF CBA IFA
Synonyms
GABAAR IgG Titr CSF CBA IFA
Category
coagulation
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
CPT
82977
SNOMED
3110003
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like seizures, muscle spasms, or unexplained movement disorders. It could also be used to evaluate conditions like epilepsy, brain injuries, or metabolic disorders affecting GABA production.

What to Expect Before the Test

You’ll have a lumbar puncture (spinal tap) where fluid is gently taken from your lower back. The procedure is quick but may cause mild discomfort. You’ll need to stay still afterward to avoid headaches.

What the Results Mean

Results are compared to typical GABA levels in healthy CSF, though exact ranges vary by lab. Very high or low levels may indicate neurological issues, but interpretation depends on your full medical history and symptoms.

Common Conditions Linked to GABA Levels

Abnormal GABA levels in CSF can be linked to epilepsy, certain brain tumors, or metabolic disorders like mitochondrial diseases. It’s not a standalone test but often used alongside other diagnostic tools.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF GABA Level

Frequently asked questions

What causes abnormal GABA levels in CSF?
GABA levels can be affected by genetic disorders, brain injuries, epilepsy, or metabolic conditions. Your doctor may also consider medications or other treatments you’re taking.
How often should I get this test?
Frequency depends on your symptoms and diagnosis. Your doctor will determine if repeat testing is needed, often based on ongoing treatment or worsening conditions.
Is there anything I should avoid before the test?
Avoid heavy lifting or strenuous activity for 24 hours before the test to reduce risk of complications. Follow any specific instructions your doctor provides.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy