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Gamma-Aminobutyric Acid (GABA)/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

This specialized urine test measures gamma-aminobutyric acid relative to creatinine, which helps account for differences in urine concentration.

Quick summary

["The result provides a urine measurement of GABA that is adjusted for urine concentration."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26581-9
Short code
GABA/Creat Ur-sRto
Synonyms
GABA/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Gamma-aminobutyric acid, or GABA, is a signaling molecule in the nervous system. This test measures the amount of GABA in urine in relation to creatinine, a substance used to assess how concentrated the urine is.

Why might I need this test?

This is a specialized test that may be used to evaluate GABA metabolism or changes in neurotransmitter-related substances. A clinician determines whether it is appropriate based on symptoms, other laboratory results, and possible treatments or exposures.

How is the test performed?

A urine sample is tested to determine the concentrations of GABA and creatinine. The laboratory then calculates the GABA-to-creatinine ratio, which helps reduce the effect of variations in urine dilution.

How do I prepare for the test?

Follow any collection instructions provided by your healthcare professional. These may include collecting a first-morning urine sample or avoiding certain foods, medicines, or supplements for a specified period. Do not stop prescribed medicines unless your clinician advises you to do so.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A higher or lower ratio may reflect altered GABA metabolism, medication effects, dietary factors, or other changes affecting GABA excretion. Urine concentration and kidney function can also influence the ratio, so an abnormal result should be interpreted alongside creatinine levels and the rest of the clinical picture.

Short name

Urine GABA/Creatinine Ratio

Frequently asked questions

Why is the result reported as a ratio?
Urine concentration can vary substantially. Comparing GABA with creatinine helps adjust the GABA measurement for urine dilution.
Is this the same as a blood GABA test?
No. This test uses urine and may be ordered only in specialized situations. Blood and urine GABA measurements should not be assumed to be interchangeable.
What if my urine GABA/creatinine ratio is abnormal?
Your clinician will consider the ratio together with symptoms, medications, diet, and other laboratory tests. An isolated abnormal value does not by itself establish a diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy