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Fasting Total Protein with Albumin Ratio (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of your total protein (including albumin and other proteins) to your albumin level in your blood. It helps assess protein balance and potential issues like malnutrition or kidney problems.

Quick summary

["A lower albumin-to-total protein ratio may signal protein loss or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33085-2
Short code
GA from BPD.Tokyo86
Synonyms
GA from BPD.Tokyo86
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-estimated-from-bpd-tokyo
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect conditions like malnutrition, kidney disease, liver disease, or certain infections. It can also help monitor protein levels in people with chronic illnesses or those receiving certain treatments.

What to Expect Before the Test

You’ll typically fast for 8–12 hours before this test. Avoid alcohol and certain medications that may affect protein levels. Bring a list of any medications you’re taking to your doctor.

How the Test Works

A blood sample is drawn from a vein in your arm. The sample is sent to a lab where proteins are measured using standard laboratory techniques, including separation and quantification methods.

What the Results Mean

Results are expressed as a ratio (e.g., 1.5:1). A lower ratio may indicate protein loss, while a higher ratio could suggest dehydration or overhydration. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein:Albumin Ratio

Frequently asked questions

What does a low albumin-to-total protein ratio mean?
A lower ratio may signal conditions like protein-losing enteropathy, kidney disease, or severe malnutrition. It can also indicate inflammation or infection, as albumin is often reduced during these states. Your doctor will evaluate results alongside other symptoms and tests.
How often should I get this test?
This test is usually ordered as needed, depending on your symptoms or medical condition. If you have chronic kidney or liver disease, your doctor may recommend periodic monitoring. Follow-up frequency depends on your specific diagnosis and treatment plan.
Can diet affect this test result?
Yes, diet can influence protein levels. High-protein diets may temporarily raise total protein, while low-protein diets could lower it. Fasting is critical to ensure accurate results, so avoid unusual dietary changes before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy