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Serum or plasma concentration of free fatty acids (medium-chain and long-chain)

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of free fatty acids in your blood, which are important for energy production and other metabolic processes.

Quick summary

["Understanding your free fatty acid levels can help assess how your body uses fat for energy and identify potential metabolic concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33088-6
Short code
GA from CL.Yarkoni85
Synonyms
GA from CL.Yarkoni85
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-estimated-from-clavicle-length-yarkoni
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms related to metabolic disorders, such as unexplained weight changes, fatigue, or signs of lipid metabolism issues. It could also be part of a broader evaluation for conditions like diabetes, thyroid disorders, or liver disease.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the blood draw if your provider specifies it. Avoid smoking or consuming alcohol for a few hours beforehand.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm. The sample is then sent to a lab for analysis. The test measures the total concentration of free fatty acids, including both medium- and long-chain types.

What the Results Mean

Results help determine if your body is efficiently processing fats. Elevated levels may suggest conditions like hyperlipidemia or metabolic syndrome, while very low levels could indicate malabsorption or other metabolic issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Free fatty acids play a critical role in energy storage and release. Abnormal levels can indicate underlying metabolic dysfunctions, such as impaired fat metabolism, endocrine disorders, or conditions affecting nutrient absorption. Your provider will use these results alongside other clinical findings to guide diagnosis and treatment.

Short name

Free Fatty Acids (FFA) Profile

Frequently asked questions

What causes free fatty acid levels to be checked?
Your provider may check free fatty acid levels if you have symptoms like unexplained weight changes, fatigue, or signs of metabolic issues (e.g., high cholesterol, diabetes, or thyroid problems). It may also be part of routine metabolic screening or monitoring for conditions like liver disease.
How do free fatty acids relate to other tests?
Free fatty acid levels are often measured alongside other lipid panels (like triglycerides or cholesterol) to assess overall fat metabolism. They may also be reviewed with glucose or thyroid hormone tests if metabolic concerns are suspected.
Can lifestyle changes affect free fatty acid test results?
Yes, diet, exercise, and fasting status can influence results. For example, fasting can temporarily increase free fatty acids as your body breaks down stored fat. Your provider will consider these factors when interpreting your results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy