Gamma-Glutamyl Transferase (GGT) in Serum

Why Is This Test Done?

Doctors may order a GGT test to check for liver damage or disease, monitor liver function after treatment, or investigate symptoms like jaundice (yellow skin), fatigue, or abdominal pain. It can also help detect conditions like cirrhosis, hepatitis, or bile duct blockages.

What Does a High or Low GGT Level Mean?

Elevated GGT levels may suggest liver problems, heavy alcohol use, or certain medications. Low levels are less common but could indicate liver disease or other conditions affecting enzyme production. Results alone don’t diagnose a problem—your doctor will consider them with other tests and symptoms.

How Is This Test Performed?

A blood sample is taken from a vein in your arm. The blood is sent to a lab where it’s analyzed to measure GGT activity. No special preparation is usually needed, but your doctor may advise avoiding alcohol or certain medications before the test.

What Are Common Causes of Abnormal Results?

GGT levels can rise due to liver diseases (like hepatitis or cirrhosis), alcohol consumption, certain medications (e.g., antibiotics, antifungals), or bile duct issues. Low levels may rarely occur with liver disease or metabolic disorders, but this is less common.