Cystatin C Serum Concentration
This test measures the level of cystatin C, a protein produced by all cells in the body that helps regulate cell growth. It’s often used to assess kidney function.
["Cystatin C helps evaluate kidney health beyond traditional blood pressure and fluid balance measures."]
Key facts at a glance
- LOINC
- 104264-7
- Short code
- GALC CSF LC/MS/MS-cCnc
- Synonyms
- GALC CSF LC/MS/MS-cCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 0
- Ref high
- 2
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- lc-ms-ms
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your doctor may order a cystatin C test to check how well your kidneys are working, especially if you have high blood pressure, diabetes, or other conditions that can affect kidney function. It can also be used alongside other tests to monitor kidney disease progression or guide treatment decisions.
How Is the Test Performed?
A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure cystatin C levels. No special preparation is needed, but you may be asked to avoid certain medications or foods for a short time if instructed by your doctor.
What Do Results Mean?
Higher than expected cystatin C levels may indicate kidney problems, while lower levels might suggest kidney function is better than expected. Your doctor will interpret results in the context of your overall health and other tests.
Common Causes of Abnormal Results
Elevated cystatin C can be due to kidney disease, dehydration, muscle disorders, or certain medications. Lower levels may occur with overhydration or in people with very low muscle mass. Always discuss results with your healthcare provider.
Reference range
NCBI: SCC <2.0 ng/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Cystatin C
Frequently asked questions
How often do I need this test?
Can I eat or drink before the test?
What if my results are out of the normal range?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy