Serum Protein Electrophoresis (with Abnormal Fraction Measurement)
This test measures the distribution of different protein fractions in your blood serum using electrophoresis, a method that separates proteins based on size and charge. It helps identify abnormalities in protein levels that may indicate conditions like infections, autoimmune diseases, or certain cancers.
["This test helps diagnose and monitor conditions affecting protein balance in your blood."]
Key facts at a glance
- LOINC
- 53593-0
- Short code
- Gamma 2 glob abnormal MFr SerPl Elph
- Synonyms
- Gamma 2 glob abnormal MFr SerPl Elph
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 7.35
- Ref high
- 7.45
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Electrophoresis splits blood proteins into bands (fractions) based on their electrical charge and size. The test detects variations in these fractions, such as elevated or low levels of specific proteins like globulins, albumin, or immunoglobulins. Abnormal patterns may signal underlying health issues.
Why It’s Ordered
Your healthcare provider may recommend this test if you have symptoms like fatigue, unexplained weight loss, swelling, or if tests suggest conditions like multiple myeloma, lymphoma, or chronic infections. It’s also used to monitor treatment progress for certain diseases.
Common Conditions Linked to Abnormal Results
Abnormal results may indicate conditions such as multiple myeloma (cancer of plasma cells), Waldenström macroglobulinemia (a type of lymphoma), autoimmune diseases (e.g., rheumatoid arthritis), or chronic infections (e.g., hepatitis). High globulin levels could also suggest inflammation or chronic disease.
Sample Collection and Preparation
A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum (the liquid part after clotting), which is then analyzed. No special preparation is needed, but fasting may be advised depending on your provider’s instructions.
Reference range
NCBI: pH 7.35-7.45N/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Serum Protein Electrophoresis
Frequently asked questions
What does an abnormal result mean?
How often will I need this test?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy