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Serum Immunoglobulin G2 (IgG2) Quantification by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G2 (IgG2), a type of antibody in your blood. IgG2 plays a key role in fighting certain infections.

Quick summary

["IgG2 helps your immune system defend against bacteria and some viruses; levels may vary with health conditions or immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34184-2
Short code
Gamma glob 24h MFr Ur
Synonyms
Gamma glob 24h MFr Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG2 is one of five main classes of antibodies (immunoglobulins) produced by your immune system. It is particularly important for protecting against bacterial infections. Your body makes IgG2 in response to certain vaccines and infections. Levels can change depending on your immune health, past illnesses, or immune system responses.

Why Might Your Doctor Order This Test?

A doctor may order this test if you have symptoms like frequent infections, unusual responses to vaccines, or conditions affecting your immune system. It can also help diagnose or monitor certain immune-related disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is processed to separate the serum (liquid part without clots) for testing. This test is typically done using serum electrophoresis, a method that separates proteins in the blood based on size and charge.

What Are Common Causes of Abnormal Results?

Low IgG2 levels may suggest a weakened immune response, possibly due to genetic conditions (like selective IgA deficiency), certain autoimmune diseases, or long-term use of immunosuppressive medications. High levels might indicate chronic infections or certain immune system activations.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

IgG2 levels can be important for diagnosing or managing conditions affecting immunity, such as hypogammaglobulinemia (low antibody levels), certain autoimmune diseases, or evaluating vaccine responses. It can also help identify if your immune system isn’t producing enough antibodies to fight infections effectively.

Short name

IgG2 Level

Frequently asked questions

What does a low IgG2 level mean?
A low IgG2 level may indicate a reduced ability to fight certain types of bacterial infections or may be linked to an underlying immune disorder. Your doctor will consider your overall health and other test results to understand the cause and recommend appropriate treatment or monitoring.
How often should I expect this test to be repeated?
The frequency depends on your medical condition and treatment plan. If you have a known immune disorder, your doctor may schedule follow-up tests every few months or as needed. For routine check-ups or vaccine responses, testing might be less frequent.
Can diet or lifestyle affect IgG2 levels?
While diet and lifestyle factors can influence overall immune health, IgG2 levels are primarily determined by your immune system’s response to infections, vaccines, and genetic factors. Your doctor will focus on medical reasons if IgG2 levels are abnormal.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy