Immunoglobulin G (IgG) Subclass 2 Quantification by Serum Protein Electrophoresis

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of a weakened immune system, recurrent infections, or if you’re being evaluated for conditions like chronic infections, autoimmune diseases, or certain immune deficiencies. It may also be used to monitor treatment progress in patients with known IgG2-related issues.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into a vein (usually in your arm) to draw a blood sample. The process is quick and typically painless. You may feel a slight pinch or discomfort, but most people tolerate it well.

What the Test Results Mean

IgG2 is one of five subclasses of IgG antibodies. Low levels may suggest an immune deficiency or certain autoimmune conditions, while high levels could indicate chronic infections or other underlying health issues. Your results will be compared to standard reference ranges provided by your lab.

Common Conditions Monitored or Diagnosed

IgG2 levels are often checked in patients with recurrent bacterial infections, particularly those caused by encapsulated bacteria (like *Streptococcus pneumoniae* or *Haemophilus influenzae*). It may also be useful in diagnosing or managing conditions like common variable immunodeficiency (CVID) or certain autoimmune diseases.