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Serum Protein Electrophoresis (Qualitative) with Mass Concentration Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of different protein types in your blood using electrophoresis, a method that separates proteins based on size and charge.

Quick summary

["Electrophoresis helps identify abnormal protein patterns that may signal conditions like multiple myeloma, liver disease, or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2875-3
Short code
Gamma glob Snv Elph-mCnc
Synonyms
Gamma glob Snv Elph-mCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis splits blood proteins into fractions (e.g., albumin, globulins) and quantifies their relative amounts. The mass concentration results help assess protein balance, which can reveal hidden imbalances in immune, liver, or kidney function.

Why It’s Ordered

Your doctor may request this test to diagnose or monitor conditions like chronic infections, autoimmune diseases (e.g., rheumatoid arthritis), or inherited protein disorders. It’s also used to screen for plasma cell disorders (e.g., multiple myeloma) or detect liver/kidney dysfunction.

Sample Preparation

A blood sample is drawn, and serum (liquid part after clotting) is prepared for analysis. No special preparation is needed, but fasting may be advised if your doctor specifies it.

Common Conditions Monitored

Abnormal electrophoresis patterns may indicate elevated or low levels of specific proteins, which can signal conditions like monoclonal gammopathy (e.g., myeloma), hypoalbuminemia, or chronic inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

How long will the results take to return?
Results typically arrive within 1–3 business days, depending on lab volume. Follow-up with your doctor to discuss findings.
What does a ‘spike’ in gamma globulins mean?
A spike in gamma globulins often points to immune system overactivity, such as chronic infections, autoimmune diseases, or certain cancers. Your doctor will interpret results in context with your symptoms and other tests.
No special diet is required unless your doctor advises fasting for another reason. Focus on hydration and rest before your blood draw.
Do I need to avoid certain foods before this test?
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy