Skip to content

Gas Chromatography/Mass Spectrometry (GC/MS) for Volatile Organic Compounds in Blood

Published: August 9, 2026Updated: August 16, 2026

This test measures a range of naturally occurring chemicals in your blood that can be released by cells or tissues, often used to detect metabolic or systemic conditions.

Quick summary

["Helps identify unusual chemical patterns that may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24344-4
Short code
Gas + CO Pnl BldV
Synonyms
Gas + CO Pnl BldV
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Measured?

This test analyzes volatile organic compounds (VOCs) in your blood, including gases like methane, benzene, and other small molecules. These chemicals can vary based on metabolism, diet, exposure, or health conditions.

Why Is This Test Done?

Doctors may order this test to investigate unexplained symptoms, metabolic disorders, or conditions like mitochondrial disorders, where abnormal chemical byproducts can appear in the blood.

Sample Collection and Preparation

A blood sample is collected via a vein, typically in the arm. The sample is processed to isolate VOCs, which are then analyzed using advanced GC/MS technology for precise detection.

Common Uses and Conditions

This test is often used in research or specialized clinical settings to support diagnoses of rare metabolic diseases, organ dysfunction, or exposure-related health concerns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Volatile Organic Compound (VOC) Blood Profile

Frequently asked questions

Will I feel pain during the blood draw?
You may feel a slight pinch or discomfort during the needle insertion, but it usually lasts only a few seconds. Most people describe it as mild and manageable with ice or distraction.
How long will it take to get results?
Results may take several days to weeks, depending on lab processing and specialized analysis. Your healthcare provider will discuss timelines with you.
Can diet or medications affect this test?
Certain foods, supplements, or medications (e.g., antibiotics, certain vitamins) can influence VOC levels. Your provider may ask you to avoid specific substances before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy