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Gastric pH and Carbon Dioxide Content (Serum/Plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures the pH level and carbon dioxide content in your stomach fluid, often used to assess acidity and digestive function.

Quick summary

["Helps diagnose acid-related digestive issues or evaluate stomach function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
60819-0
Short code
Gastric pCO2
Synonyms
Gastric pCO2
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
gastric-tonometry
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like heartburn, frequent stomach pain, nausea, or unexplained weight loss. It may also be used to check for conditions like gastroesophageal reflux disease (GERD), ulcers, or other stomach disorders that affect acid production or digestion.

What to Expect Before the Test

You may be asked to fast for a few hours before the test, depending on your doctor’s instructions. Avoid eating or drinking anything except water. If you’re taking certain medications (like acid reducers), your provider may ask you to stop them temporarily.

How the Test Is Performed

A small sample of your stomach fluid is collected using a thin tube inserted through your nose into your stomach. The fluid is then sent to a lab for analysis of pH and carbon dioxide levels. The procedure is usually quick and painless but may cause mild discomfort.

What the Results Mean

Results help determine if your stomach produces too much or too little acid, which can indicate conditions like hyperchlorhydria (excess stomach acid) or hypochlorhydria (low stomach acid). Your doctor will interpret the results in relation to your symptoms and medical history.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Gastric pCO₂ Profile

Frequently asked questions

How does this test help doctors diagnose conditions?
This test provides critical insights into stomach acidity and carbon dioxide balance, which can reveal issues like GERD, peptic ulcers, or other digestive disorders. High or low pH levels may point to abnormal acid secretion or motility problems, guiding treatment decisions such as medication adjustments or lifestyle changes.
What are the typical reference ranges for this test?
Reference ranges for pH and carbon dioxide in stomach fluid vary by lab and method. Your doctor will provide your specific results and compare them to what’s appropriate for your condition.
Can I eat or drink anything before this test?
Follow your doctor’s instructions carefully. Typically, you’ll need to fast for a few hours before the procedure, but avoid solid foods and most liquids (except water) unless directed otherwise.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy