Anti-Ganglioside Antibody Profile (GD1a, GD1b, GT1b) by Line Immunoblot
This test measures antibodies against specific ganglioside molecules (GD1a, GD1b, GT1b) in your blood using a line immunoblot method. These antibodies may be linked to certain neurological conditions.
This screening helps identify potential immune-related nerve damage or autoimmune responses.
Key facts at a glance
- LOINC
- 82396-3
- Short code
- GD1a Gangl IgG+IgM Ser Ql Line blot
- Synonyms
- GD1a Gangl IgG+IgM Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects antibodies targeting three types of gangliosides: GD1a, GD1b, and GT1b. Gangliosides are complex sugars found on nerve cell surfaces. If your immune system produces these antibodies, it may indicate an abnormal immune response affecting nerves.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, or balance issues that could suggest nerve damage. It’s also used in diagnosing conditions such as Guillain-Barré syndrome or certain autoimmune neuropathies.
How the Test Works
A small blood sample is taken, and antibodies are analyzed using a line immunoblot technique. This method detects specific antibodies against ganglioside antigens on a membrane, helping identify which antibodies are present.
What to Expect Before the Test
No special preparation is needed. You may have a slight bruise or soreness at the needle site, but this usually fades quickly. If you’re on blood-thinning medication, let your provider know before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results for these antibodies may suggest an autoimmune response affecting peripheral nerves. While not definitive, they can support a diagnosis of conditions like Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, or other neuropathies. Further testing may be needed to confirm the diagnosis and guide treatment.
Short name
Anti-Ganglioside Antibodies (Screen)
Frequently asked questions
What does a positive result mean?
Can this test be used to diagnose Guillain-Barré syndrome?
How soon will I get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy