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Ganglioside GM1 (by Line Blot)

Published: August 9, 2026Updated: August 16, 2026

This test detects specific gangliosides, including GM1, in your blood using a line blot immunoassay. It may help identify certain genetic or metabolic conditions affecting lipid metabolism.

Quick summary

["This test helps diagnose rare genetic disorders linked to abnormal lipid storage."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82397-1
Short code
GD1a Gangl IgM Ser Ql Line blot
Synonyms
GD1a Gangl IgM Ser Ql Line blot
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
line-blot
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test identifies the presence and relative amounts of ganglioside GM1, a type of complex carbohydrate-lipid molecule found in cell membranes. GM1 is often analyzed in conditions where lipid metabolism is disrupted, such as certain lysosomal storage diseases.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like developmental delays, movement disorders, or neurological issues that could be linked to GM1-related disorders. It’s sometimes used in research or specialized diagnostic settings for suspected metabolic diseases.

How the Test Works

A small blood sample is drawn and analyzed using a line blot immunoassay. This method detects specific antibodies or markers that bind to GM1, creating visible lines on a test strip that indicate presence and concentration.

Preparation and Sample Collection

No special preparation is needed. A simple blood draw is performed by a healthcare professional. The sample is then sent to a lab for analysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated or abnormal GM1 levels may suggest certain lysosomal storage disorders, such as GM1 gangliosidosis, which can affect the nervous system and other organs. Early detection can guide treatment decisions and management strategies.

Short name

GM1 Blot Test

Frequently asked questions

What does a positive result mean?
A positive result may indicate an abnormal level of GM1, which could be associated with a genetic disorder affecting lipid metabolism. This finding would need further evaluation by a specialist to determine the exact cause and next steps.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your healthcare provider will discuss the results with you.
Can lifestyle changes affect this test?
No specific lifestyle changes are known to influence GM1 levels in this test. However, always follow your healthcare provider’s advice regarding diet, medications, or other factors that may impact your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy