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Anti-Ganglioside Antibody Profile (Line Blot, Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against specific ganglioside molecules in your blood, which may help diagnose certain neurological conditions.

Quick summary

Helps identify potential nerve damage or autoimmune responses linked to rare neurological disorders.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82398-9
Short code
GD1b Gangl IgG+IgM Ser Ql Line blot
Synonyms
GD1b Gangl IgG+IgM Ser Ql Line blot
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
line-blot
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Ganglioside?

Gangliosides are complex lipids found in nerve cell membranes. They play a role in cell signaling and can be targeted by the immune system in some diseases.

Why Is This Test Done?

Doctors may order this test if you have symptoms like weakness, numbness, or balance issues that suggest nerve damage, especially in conditions like Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The serum is then analyzed using a line blot assay to detect antibodies against specific ganglioside antigens.

What Might the Results Indicate?

Positive results may suggest an autoimmune response targeting nerve cells, potentially linked to neurological disorders. However, results alone do not diagnose a condition; they are often used alongside clinical findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test helps support a diagnosis by identifying antibodies that may contribute to nerve damage or inflammation. It is particularly useful in cases where other tests are inconclusive or symptoms suggest a specific type of neuropathy.

Short name

Anti-Ganglioside Antibody Screen

Frequently asked questions

Why do I need this test if I have nerve symptoms?
Your doctor may recommend this test to investigate potential autoimmune causes of your symptoms, such as nerve inflammation or damage. Ganglioside antibodies can be a marker for certain neurological conditions.
What are the common symptoms this test helps diagnose?
This test is often used in patients with symptoms like muscle weakness, numbness, balance problems, or pain that may suggest nerve-related disorders, such as Guillain-Barré syndrome or chronic neuropathy.
How soon will I get my results?
Results are typically available within 3–7 business days, depending on lab processing times. Your healthcare provider will discuss them with you during your follow-up.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy