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GDF15 (Growth Differentiation Factor 15) [Mass/Volume] in Serum or Plasma by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

GDF15 is a protein released by cells under stress, and this blood test measures its concentration in serum or plasma using an immunoassay method. It is used mainly as a research and clinical aid to assess certain conditions.

Quick summary

["This test measures the level of GDF15, a stress-response protein, in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92665-9
Short code
GDF-15 SerPl IA-mCnc
Synonyms
GDF-15 SerPl IA-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Being Measured

GDF15 (growth differentiation factor 15) is a protein that many types of cells produce when they are under stress, injured, or not getting enough oxygen or nutrients. It is sometimes found in higher amounts in the blood in various medical conditions, so doctors and researchers use this test to measure its level.

How the Test Works

A blood sample is collected from a vein in your arm and sent to a laboratory. In the lab, a specific immunoassay method is used to detect and measure the amount of GDF15 present in the serum or plasma portion of your blood. The result is usually reported as a concentration.

What to Expect

Collecting the blood sample is quick and similar to any routine blood draw. You may feel a brief pinch when the needle goes in, and a small bandage is placed afterward. For many blood tests, fasting or other preparation may be requested, so follow any instructions your healthcare provider gives you.

Results and What They Mean

Your result is compared with a reference range that the performing laboratory provides, because ranges can differ between labs and methods. GDF15 levels can rise in many situations, so a single result is generally interpreted alongside your symptoms, medical history, and other test results rather than on its own.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

GDF15 is a biomarker that can be elevated in a wide range of conditions, including metabolic, cardiovascular, inflammatory, and other disorders, and it is used largely as a supportive or research tool. Because it is not specific to any one disease, its clinical significance depends on being interpreted together with other findings by a healthcare professional.

Short name

GDF15

Frequently asked questions

Does an abnormal GDF15 result mean I have a specific disease?
No. GDF15 can be higher in many different situations and conditions, so it cannot by itself confirm or rule out a particular disease. Your provider will consider it together with your symptoms and other tests.
Do I need to fast before this test?
Not all labs require fasting for this test, but some tests do. Follow the preparation instructions given by your healthcare provider or the laboratory to be safe.
Is GDF15 a routine test?
GDF15 testing is more commonly used in research or specialized clinical settings than as a routine screening test. Your healthcare provider can explain whether and why it is being ordered in your case.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy